Potentiation of thiopental anesthesia by adrenaline
نویسندگان
چکیده
منابع مشابه
Hemodynamic Changes during Thiopental Anesthesia
Thiopental, monosodium 5-ethyl-5(1-methylbutyl) -thiobarbiturate, is extensively used in clinical anesthesia either as a primary anesthetic agent for short surgical procedures or as a supplementary drug in conjunction with other anesthetics. Fatalities have been attributed to its use (1, 2) and cardiac arrest has occurred following its administration to patients under spinal anesthesia (3). Mos...
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It has already been reported that epinephrine as well as certain other substances, when injected into ani mals on awakening from barbiturate anesthesia, causes a return to sleep (1). In an attempt to further the understanding of the interaction between catecholamines and adrenergic blocking agents in barbiturate anesthesia, the ability of alpha or beta blocking agent to antagonize the catechol ...
متن کاملThiopental Sodium Anesthesia Following Premedication of Rabbits with Vitamin C
Rabbits are widely used as laboratory animals for experimental surgery. Anesthesia of rabbits may present complications unless the method is easy to apply and safe to use. In present study, effects of different dosages of vitamin C on thiopental sodium induced anesthesia in 25 male New Zealand white rabbits were studied. In the animals that had not received vitamin C treatment before thiopental...
متن کاملMechanism of potentiating action of epinephrine on thiopental anesthesia.
A number of papers have been presented in support of the concept that epinephrine potentiates barbiturate anesthesia in experimental animals (1-3). Recently, Mazel et al. (4) reported that epinephrine increased the brain level of barbital above controls and suggested that epinephrine may affect the permeability of the blood-brain barrier as well as other barriers. However, mechanism of the pote...
متن کاملInvolvement of phosphoinositide metabolism in potentiation by adrenaline of ADP-induced aggregation of rabbit platelets.
Changes in phosphoinositide metabolism were examined in washed rabbit platelets stimulated with 0.5 microM-ADP, 50 microM-adrenaline, or ADP and adrenaline in combination. Adrenaline does not stimulate platelet aggregation when used alone, but does potentiate aggregation stimulated by ADP. In platelets prelabelled with [32P]Pi and [3H]glycerol, adrenaline was found to potentiate the ADP-induced...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1971
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.67.193